Resins (GE Healthcare) to give a final bed. As member of the BioProcess resins range, Capto adhere meets industrial demands with security of supply and comprehensive technical and regulatory support. Nuvia aPrime 4A Resin (Bio-Rad Laboratories) or Capto adhere or Capto adhere ImpRes Multimodal Chromatography.Capto adhere is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development.For optimal performance of Capto adhere, screening/optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor 96-well filter plates. Capto adhere ImpRes multimodal chromatography resin This multimodal, strong anion exchange resin supports effective mAb polishing in the second or third step of a purification scheme downstream of the protein A capture step.Together with a Protein A capture step, like MabSelect SuRe, Capto adhere allows the design of a two-step chromatographic process for Mabs. Chromatography with Capto Adhere in bindingmode with elution by linear salt gradient at pH 7.5 resulted in optimal yield, purity and HCP reduction factor.Capto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. The strong multimodal ligand gives a different selectivity compared to traditional ion exchangers.Composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The high chemical stability of Capto resins lets you perform cleaning-in-place procedures with ease.3 to 12 pH Stability, BioProcess Resin, Multim - GHC-F (Additional S&H or Hazmat. Capto adhere is a multimodal BioProcess resin designed for post-protein A purification of monoclonal antibodies (MAbs) at process scale. Cytiva Capto Adhere ImpRes, 25mL, 40um Particle Size, 45 to 85mg Mab mL.
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